Determination of the Concentration Blends of Superdisintegrant for Fast Disintegrating Tablets

In this research work, different blends of superdisintegrants with different ratio in fixed concentration were taken and placebo tablets were formulated and evaluated with a view to optimize a formula and concentration blends of superdisintegrants for Fast Disintegrating Tablets (FDT). In this research work three superdisintegrants, viz. Crosscarmellose, Crospovidone and Sodium Starch Glycolate were used in different ratio (1:1, 1:2, 2:1) in fixed concentration of 4% w/w in combination in each batch. Six blends were prepared and 3 batches of tablets of each formulation code blend were formulated and evaluated for pre-compression parameters like Compressibility, Hausner’s ratio, Bulk density, Tapped density and postcompression parameters like Hardness, Weight variation, Disintegration time, Dispersion time, Friability, Wetting time, Water absorption ratio. Based on results it revealed that the formulation code blend A3 which had Croscarmellose, Crosspovidone in ratio 1:2 (4%w/w) emerged as best blend of superdisintegrants for FDT formulation. To optimize the formula of A3 blend, Paracetamol FDT was formulated and evaluated using the concentration blend of A3; three batches were formulated and evaluated for all above parameters and in-vitro drug release (pH5.8 phosphate buffer) and disintegration time was found between 23-27 seconds and release was more than 80% in 30 minute. We can conclude that a good FDT can be formulated using the above A3 blend concentration. INTRODUCTION: Oral route of administration still enjoys, as most preferred route because of its numerous advantages. The most popular oral dosage forms are tablets and capsules. However, one important drawback of these dosage forms is the need to swallow. Many patients express difficulty in swallowing tablets and hard gelatin capsules, resulting in non-compliance and ineffective therapy . Recent advances in Novel Drug Delivery Systems (NDDS) aims to formulating a dosage form of drug molecules for convenient administration and to achieve better patient compliance. One such approach leads to development of fast dissolving/ disintegrating tablets . Advantages of this drug delivery system include convenience of administration and accurate dosing as compared to liquids, easy portability, ability to provide advantages of liquid medication in the form of solid preparation, ideal for pediatric and geriatric patients and rapid dissolution/absorption of the drug, which may produce rapid onset of action. Some drugs are absorbed from mouth, pharynx and esophagus as the